{"product_id":"metagenics-painx-advanced-42-caps","title":"Metagenics - PainX Advanced 42 caps","description":"\u003cp\u003e\u003cem\u003e\u003cstrong\u003e(Previously known as Bio Absorb PEA Advanced)\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHigh Strength, Enhanced Absorption PEA For Mild Nerve Pain Combined With Saffron.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFor the relief of mild nerve pain, neuralgia, and compression neuropathy.\u003c\/li\u003e\n\u003cli\u003eBreaks the pain cycle by targeting drivers of pain amplification, is analgesic and enhances endocannabinoid activity.\u003c\/li\u003e\n\u003cli\u003eA highly bioavailable form of PEA using the Levagen+™ (LipiSperse®) delivery system, with affron® and vitamin B1.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eClinical Benefits:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePainX PEA Advanced relieves neuropathic pain, such as sciatica, neuropathies and neuralgia.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eClinical Research for PEA\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePalmitoylethanolamide (PEA) is neuroprotective, anti-inflammatory, \u003c\/strong\u003e\u003cstrong\u003eand analgesic4 due to its endocannabinoid (eCB) action. \u003c\/strong\u003ePEA affects eCB  signalling through peroxisome proliferator-activated receptor alpha (PPAR-α)  activation6and is capable of exerting antiallodynic and anti-hyperalgesia  effects by downmodulating both microglial and mast cell activity which has led to its use for neuropathic pain. Both TRPA1 (transient receptor potential ankyrin 1) and TRPV1 (transient receptor potential vanilloid type 1) are co-expressed in sensory neurons and are implicated in neuropathic pain, hyperalgesia and neural amplification.8Animal studies have shown that a main phytoconstitutent of saffron, safranal, desensitises TRPA1 and PEA desensitises TRPV1. In addition, vitamin B1 deficiency results in neuropathic pain and vitamin B1 was found to significantly reduce dorsal root ganglia neuron excitability \u003cem\u003ein vitro\u003c\/em\u003e, a provocating factor in central sensitisation of pain.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e1 in 5 of chronic pain sufferers have neuropathic pain. \u003c\/strong\u003ePatients presenting inadequate response to drug treatment can partly be explained by the hyperalgesia that is associated with long-term opioid use. PEA and saffron have been found to be safe to use alongside common pain medication in certain individuals*.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003e\u003cstrong\u003ePEA, Saffron and Vitamin B1 in the Pain Cycle\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLevagen+™ uses LipiSperse® technology for enhanced absorption and is 70% better absorbed (Figure 2) leading to greater plasma levels over time compared to a standard PEA. \u003c\/strong\u003e600 mg\/d of Levagen+™ PEA is likely to equate to consuming 1,000 mg of a standard micronized PEA. Practitioners can expect Levagen+™ to produce greater efficacy and to last longer in the body.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cmeta charset=\"utf-8\"\u003eLevagen+™ PEA vs Standard PEA.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eLevagen+™ is owned by Gencor Pacific Limited. affron® is a registered trademark of Pharmactive Biotech Products, S.L.\u003cbr\u003e*Always check patient medications for interactions and safety.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAdults: Take 1 capsule twice daily.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThis medicine is not to be used for more than 21 consecutive days, and may interact with other prescription analgesic medicines. Please consult your healthcare practitioner before use. Suitable for individuals 18 years and over. Vitamins supplements should not replace a balanced diet.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eStore below 30°C.\u003c\/p\u003e","brand":"Bodywise Herbal Dispensary","offers":[{"title":"Default Title","offer_id":52730946650388,"sku":null,"price":95.0,"currency_code":"NZD","in_stock":false}],"url":"https:\/\/bodywiseherbaldispensary.co.nz\/products\/metagenics-painx-advanced-42-caps","provider":"Bodywise Herbal Dispensary","version":"1.0","type":"link"}