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Designs for Health - ProbioSpore 60caps
Designs for Health - ProbioSpore 60caps
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Designs for Health - AU
- Support gastrointestinal health with Probiospore
- Contains 4 billion CFU of Bacillus coagulans (IS2) per capsule
- Improves bowel regularity
- Maintains intestinal good flora
- Vegan friendly
Education:
Designs for Health ProbioSpore is a unique spore-based probiotic containing Bacillus coagulans (UNIQUE IS-2TM) as a single ingredient.
Originally named Lactobacillus sporogenes, Bacillus coagulans is a transient, gram-positive, lactic acid-producing bacteria that is protected from stomach acid by a protein-based spore coating. Instead of dying off as a result of coming into contact with stomach acid, the spore coating expands, and B. coagulans begins to germinate as it moves out of the stomach and into the duodenum where the environment is more amenable. Germination occurs between 4-6 hours after ingestion, and around 85-93% of the ingested and germinated probiotic ends up in the intestines. Further to this, its preferred growth temperature is between 35-50°C. As a result, B. coagulans displays an excellent stability profile at ambient temperatures
Once germination has taken place, B. coagulans proliferates in the distal parts of the small intestine and is able to produce the isomeric form of lactic acid. The isomeric form is unlikely to give rise to metabolic acidosis.
Being a transient and not a colonising probiotic, B. coagulans does not remain in the intestinal tract for long and begins to be excreted via the faeces around seven days after supplementation ceases. Despite such a short period of time of activity in the bowel, B. coagulans affects the microbial colony in that it helps to regulate beneficial flora and inhibit the proliferation of opportunistic bacteria via the production of “bacteriocin-like substances” and short-chain fatty acids (SCFAs). These compounds support the health of the GI lining and provide direct antagonism to microbial pathogens.
Bacillus coagulans and Digestion
B. coagulans is also able to produce several enzymes that assist digestive processes such as nutrient breakdown and absorption. Some of these enzymes include lipase, protease, α-amylase and both α- & β-galactosidase and assist with protein and carbohydrate digestion.2 Absorption is also facilitated as B. coagulans can reduce inflammation of the gut lining and promote the health of the permeable areas of the microvilli.
Bowel Regularity
As well as digestion, B. coagulans has also been found to assist excretion. It produces metabolites such as diacetyl, SCFAs and vitamins, stimulates peristalsis, reduces amine production, reduces bowel transit time, and improves the overall health of the bowel. This in turn helps to improve bowel regularity and reduce toxin build-up.
A randomised, double-blind, placebo-controlled clinical trial performed using the Unique IS-2TM strain on 100 men and women suffering from functional constipation showed that supplementation with B. coagulans at a dose of 2bn CFU daily improved stool frequency, consistency, pain associated with defecation, and feelings of incomplete evacuation.
Pain associated with Irritable Bowel Syndrome
The specific strain Unique IS-2TM has also been the subject of a clinical trial included in a meta-analysis for its effects on medically diagnosed irritable bowel syndrome.
Daily dosing of 2 billion CFU of Unique IS-2TM daily was studied in a randomised, double-blind, placebo-controlled trial involving 108 men and women fulfilling ROME III criteria for irritable bowel syndrome. Reduction of abdominal pain and an increase in spontaneous complete bowel movements were the primary endpoints studied. Bacillus coagulans Unique IS-2TM was able to show more than a 50% pain reduction score in 90.5% of patients, and significantly reduced the total symptom severity score (including symptoms such as bloating, incomplete evacuation, urgency, straining, passage of gas, bowel habit satisfaction and stool consistency) from 26.7 to 10.6 (placebo 26.7 to 21.5) over the course of eight weeks
A meta-analysis picked up this trial as well as 41 others done on a number of different probiotic species and concluded that Bacillus coagulans Unique IS-2TM is able to effectively reduce abdominal pain associated with medical diagnosed irritable bowel syndrome
Directions for use
Adults: Take one capsule daily with water or as directed by your health professional.
Prescribing Information: Bacillus coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate the administration of antibiotics and B. coagulans preparations by at least two hours
Allergen Information
- No added: Gluten, Dairy, Egg, Sesame, Peanuts and Tree Nuts
- Free From: Artificial Flavours, Artificial Colours, Sulfites,
- Contains soybean products
- Vegan Friendly